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Intracellular pH and H+ buffering capacity in guinea‐pigs with left ventricular hypertrophy induced by constriction of the thoracic aorta
Author(s) -
Wallis WR,
Wu C,
Sheridan DJ,
Fry CH
Publication year - 1997
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1997.sp004011
Subject(s) - constriction , cardiology , medicine , thoracic aorta , muscle hypertrophy , aorta , left ventricular hypertrophy , intracellular , anatomy , chemistry , blood pressure , biochemistry
Intracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart‐to‐body weight ratio and a decrease in pHi (mean +/− S.D., 7.06 +/ࢤ 0.18 pH units in control hearts vs. 6.87 +/− 0.17 pH units in hypertrophied hearts). Intracellular H+ buffering capacity (beta) increased as pHi fell, but the value of beta was independent of hypertrophy per se.