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Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea‐pig sino‐atrial node
Author(s) -
Rigg L,
Terrar DA
Publication year - 1996
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1996.sp003983
Subject(s) - calcium , guinea pig , endoplasmic reticulum , medicine , sinoatrial node , ryanodine receptor 2 , endocrinology , cardiology , biology , ryanodine receptor , microbiology and biotechnology , heart rate , blood pressure
Ryanodine and cyclopiazonic acid were used to alter the ability of the sarcoplasmic reticulum (SR) to store calcium. Interventions of this kind significantly reduced the rate of spontaneous beating of guinea‐pig sino‐atrial node preparations. In addition, both of these drugs decreased the rate of rise and modified other characteristics of the action potentials recorded from this region. It is proposed that calcium released from the SR plays an important, previously unrecognized, role in pacemaking in the sino‐atrial node, possibly through regulation of sarcolemmal ionic currents.