The effects of sodium‐calcium exchange inhibitors on protein loss associated with the calcium paradox of the isolated Langendorff perfused guinea‐pig heart | Zendy

Chatamra KR | Zendy; Chapman RA | Zendy

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The effects of sodium‐calcium exchange inhibitors on protein loss associated with the calcium paradox of the isolated Langendorff perfused guinea‐pig heart

Author(s) -

Chatamra KR,

Chapman RA

Publication year - 1996

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/expphysiol.1996.sp003925

Subject(s) - bepridil , calcium , chemistry , guinea pig , myoglobin , sodium calcium exchanger , biophysics , sodium , medicine , endocrinology , biochemistry , pharmacology , verapamil , biology , organic chemistry

The damage done to Langendorff perfused guinea‐pig hearts by initiation of a calcium paradox, as assessed by the loss of myoglobin, is significantly reduced if inhibitors of Na(+)−Ca2+ exchange (Mn2+, Ni2+, bepridil and dodecylamine) are present when Ca2+ is repleted. This protection is not, to any major extent, due to secondary effects of these agents on the L‐type Ca2+ channels, because more specific inhibitors of the Ca2+ channels are much less effective. These results suggest that the principal route for Ca2+ entry during the calcium paradox is Na(+)−Ca2+ exchange.

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