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Penetration of small molecular weight substances through cultured bovine brain capillary endothelial cell monolayers: the early effects of cyclic adenosine 3',5'‐monophosphate
Author(s) -
Deli MA,
Dehouck MP,
Abraham CS,
Cecchelli R,
Joo F
Publication year - 1995
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1995.sp003877
Subject(s) - paracellular transport , adenosine , cyclic adenosine monophosphate , tight junction , vascular permeability , permeability (electromagnetism) , second messenger system , endothelial stem cell , chemistry , phosphorylation , medicine , adenosine monophosphate , blood–brain barrier , endocrinology , microbiology and biotechnology , biophysics , biochemistry , biology , intracellular , receptor , in vitro , central nervous system , membrane
Second messengers, such as cyclic adenosine 3',5'‐monophosphate (cAMP), have been shown to take part in the regulation of blood‐brain barrier permeability. In the present study, elevation of cAMP levels decreased sucrose (mol. wt, 342) and inulin (mol. wt, 5000) permeability across monolayers of bovine brain capillary endothelial cells as early as 1 h after exposure. Since both tracers use predominantly a paracellular pathway, we assume that cAMP may increase the tightness of the tight junctions through protein phosphorylation.