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The secretion of parathyroid hormone‐related protein in the saliva of sheep and its effects on the salivary clearance of phosphate, calcium, magnesium, potassium and sodium ions
Author(s) -
Dua K,
Abbas SK,
Care AD
Publication year - 1995
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1995.sp003869
Subject(s) - medicine , endocrinology , potassium , chemistry , saliva , calcium , parathyroid hormone , sodium , cannula , phosphate , magnesium , endogeny , calcium metabolism , hormone , biology , biochemistry , surgery , organic chemistry
Parathyroid hormone‐related protein (PTHrP(1–34)) was infused into five sheep, each fitted with a large rumen cannula. After infusion, significant increases were observed in the total and ionized calcium concentrations in plasma but not in saliva. In contrast, significant decreases in the plasma concentrations of phosphate and potassium and corresponding increases in their salivary concentrations and clearance rates were observed. The salivary concentration of endogenous PTH1P(1–34) was significantly greater than that in plasma sampled simultaneously, but during the infusion of PTHrP(1–34) both plasma and salivary concentrations of PTHrP(1–34) increased.