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Glibenclamide, a blocker of ATP‐sensitive potassium channels, reverses endotoxin‐induced hypotension in pig
Author(s) -
Vanelli G,
Hussain SN,
Aguggini G
Publication year - 1995
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1995.sp003832
Subject(s) - glibenclamide , potassium channel , antagonist , blood pressure , atp sensitive potassium channel , potassium channel blocker , pharmacology , chemistry , anesthesia , medicine , endocrinology , receptor , diabetes mellitus
In anaesthetized, mechanically ventilated, indomethacin‐treated pigs, we infused E. coli endotoxin (LPS, 20 micrograms kg‐1 h‐1, i.v.). After 150 min of endotoxaemia, 10 mg kg‐1 glibenclamide (an ATP‐sensitive K+ channel antagonist) was administered i.v. over 5 min. Vascular variables were recorded before (control), after 150 min of endotoxaemia and 5, 15 and 30 min after glibenclamide infusion. Glibenclamide transiently (within 5 min) increased systemic arterial pressure, reduced by LPS administration, without an effect on cardiac output. Our data indicate that ATP‐sensitive K+ channels may play a partial role in the vascular changes due to endotoxaemia.