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The role of parathyroid hormone‐related protein in calcium homeostasis in the fetal pig
Author(s) -
Abbas SK,
Ratcliffe WA,
Moniz C,
Dixit M,
Caple IW,
Silver M,
Fowden A,
Care AD
Publication year - 1994
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1994.sp003785
Subject(s) - calcium metabolism , medicine , endocrinology , parathyroid hormone , fetus , calcium , homeostasis , hormone , placenta , stimulation , gestation , calcium sensing receptor , biology , pregnancy , genetics
The concentrations of plasma parathyroid hormone‐like bioactivity and parathyroid hormone‐related protein (1–86) (PTHrP) immunoreactivity were both higher in fetal pigs than in their mothers during the last 3 weeks of gestation. Both activities changed inversely with alterations in the plasma ionized calcium concentration. The data suggest that PTHrP may have a role in calcium homeostasis in the fetal pig, similar to its postulated role in sheep in the stimulation of calcium transport across the placenta.