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Evidence for downregulation of hypothalamic 5‐hydroxytryptamine receptor function in endurance‐trained athletes
Author(s) -
Jakeman PM,
Hawthorne JE,
Maxwell SR,
Kendall MJ,
Holder G
Publication year - 1994
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1994.sp003780
Subject(s) - serotonergic , endocrinology , medicine , agonist , athletes , downregulation and upregulation , prolactin , endurance training , hormone , receptor , psychology , serotonin , chemistry , physical therapy , biochemistry , gene
Serum prolactin (PRL) was used as a hormone marker of serotoninergic function following oral administration of an acute dose of a serotoninergic agonist. Five male endurance‐trained athletes (ET) and five healthy non‐endurance‐trained controls (NT) were studied. The peak PRL concentration was lower (P = 0.031) for the ET athletes (486 +/‐ 208 mU l‐1; mean +/‐ S.D.) than for the NT controls (1000 +/‐ 385 mU l‐1); the total release of PRL was also lower (P = 0.042) for the ET subjects. The lower neuroendocrine response to a serotoninergic agonist in the endurance‐trained athletes suggests a downregulation of central serotoninergic receptor function in response to endurance training in man.