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Hyaluronan reduces fluid escape rate from rabbit knee joints disparately from its effect on fluidity
Author(s) -
McDonald JN
Publication year - 1994
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1994.sp003736
Subject(s) - rabbit (cipher) , anatomy , chemistry , medicine , mathematics , statistics
The effect of hyaluronan, the major viscous component of synovial fluid, on trans‐synovial flow was measured in rabbit knees. Hyaluronan reduced fluid escape rate by up to 45%. This was much less than the reduction in intra‐articular fluidity (1/viscosity). Electron micrographs supported the view that hyaluronan might be partially reflected by synovium, creating a molecular filtercake at the surface.