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Bombesin and gastrin‐releasing peptide stimulate electrogenic ion transport in cultured human endometrial epithelial cell layers
Author(s) -
Matthews CJ,
Redfern CP,
Thomas EJ,
Hirst BH
Publication year - 1993
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1993.sp003720
Subject(s) - bombesin , gastrin , gastrin releasing peptide , peptide , medicine , endocrinology , chemistry , peptide hormone , microbiology and biotechnology , biology , neuropeptide , hormone , biochemistry , receptor , secretion
Electrogenic ion transport across human endometrial epithelial cells grown as polarized monolayers on permeable supports was measured as an inward short‐circuit current (Isc; 16.2 +/− 1.1 microA/cm2). Bombesin (10(−7) M) and human gastrin‐releasing peptide (GRP; 10(−7) M) caused transient enhancement of this Isc. These effects were largely restricted to the basolateral surface of the cells; responses to apical peptide were modest in comparison with those to basolateral peptide. GRP and other bombesin‐related peptides may have a role in regulation of endometrial epithelial ion transport in vivo and thereby influence the intra‐uterine environment.