Premium
Sound stimulation increases the cerebral glucose:oxygen quotient in the fetal sheep
Author(s) -
Chao CR,
Glenford PG,
Karibo EJ,
Salha SD
Publication year - 1993
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1993.sp003718
Subject(s) - stimulation , medicine , endocrinology , oxygen , fetus , glycolysis , chemistry , biology , metabolism , pregnancy , genetics , organic chemistry
We sought to determine the cerebral metabolic fate of glucose during sound stimulation in near‐term fetal sheep. Blood oxygen content was significantly decreased by 6‐7% during sound stimulation. The cerebral glucose:oxygen quotient increased from 0.88 +/− 0.08 to 1.13 +/− 0.12 (mean +/− S.E.M., P < 0.01). This is consistent with the phenomenon of stimulated glycolysis which has been shown to increase brain lactate concentration in other models.