The role of the sodium pump and sodium‐calcium exchange in recovery from calcium overload in guinea‐pig ventricular myocytes | Zendy

Minezaki KK | Zendy; Chapman RA | Zendy

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The role of the sodium pump and sodium‐calcium exchange in recovery from calcium overload in guinea‐pig ventricular myocytes

Author(s) -

Minezaki KK,

Chapman RA

Publication year - 1993

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/expphysiol.1993.sp003706

Subject(s) - calcium , sodium , guinea pig , sodium calcium exchanger , medicine , sodium pump , chemistry , myocyte , endocrinology , cardiology , organic chemistry , ouabain

A marked increase in [Ca2+]i is provoked in isolated guinea‐pig ventricular myocytes by return to normal Tyrode solution after a period of exposure to fluid free of divalent cations. When the sarcolemma of the myocyte remains intact, [Ca2+]i falls back towards initial levels over the next 5 to 10 min in spite of the strong irreversible contracture. This recovery fails to occur if either the Na+ pump or Na(+)‐Ca2+ exchange is inhibited once [Ca2+]i has risen.

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