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Effects of D‐glucose, L‐glucose and D‐mannitol on renal calcium handling and general renal function in the rat
Author(s) -
Boland PS,
Garland HO
Publication year - 1993
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1993.sp003677
Subject(s) - renal glucose reabsorption , mannitol , endocrinology , medicine , renal function , calcium , reabsorption , chemistry , renal physiology , sodium , d glucose , renal sodium reabsorption , glucose transporter , insulin , kidney , diabetes mellitus , biochemistry , type 2 diabetes , organic chemistry
Standard renal clearance techniques were used to compare the effects of D‐glucose, L‐glucose and D‐mannitol on renal calcium handling and general renal function in the anaesthetized rat. A significant (P < 0.01) calciuresis was seen in animals infused with D‐glucose. This resulted from a decreased tubular reabsorption of calcium. A similar response was not seen with L‐glucose or D‐mannitol. The contrasting actions of the three sugars on tubular calcium transport may relate to their different transport characteristics, since only D‐glucose is actively reabsorbed. Responses of the three sugars also differed with respect to fractional fluid and sodium reabsorption which were significantly (P < 0.001) lower in animals infused with L‐glucose and D‐mannitol, and plasma insulin concentrations which were significantly (P < 0.01) elevated only in the D‐glucose group. An unexpected finding was a highly significant (P < 0.001) and progressive fall in glomerular filtration rate (GFR) in animals infused with L‐glucose. The reasons for this are not known.