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Enterocytes on rat jejunal villi but not in the crypts posses m3 mRNA for the M3 muscarinic receptor localized by in situ hybridization
Author(s) -
Przyborski SA,
Levin RJ
Publication year - 1993
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1993.sp003666
Subject(s) - crypt , in situ hybridization , jejunum , muscarinic acetylcholine receptor , enterocyte , messenger rna , biology , receptor , microbiology and biotechnology , small intestine , endocrinology , gene , biochemistry
Localization of m3 mRNA, for the expression of the M3 muscarinic receptor, along the crypt‐villus axis, was undertaken in rat jejunum by in situ hybridization. While enterocytes on the lower two‐thirds of the villi showed the presence of m3 mRNA it was absent in the crypt enterocytes. This indicates that the final locus of muscarinically activated jejunal secretion is mediated by the M3 receptor on the enterocytes of the villi and not via the crypt cells.