Voltage‐sensitive elevation of cytosolic [Ca2+] in guinea‐pig cardiac myocytes elicited by calcitonin gene‐related peptide | Zendy

Gill JS | Zendy; Moonga BS | Zendy; Huang CL | Zendy; Lu F | Zendy; Zaidi M | Zendy; Camm AJ | Zendy

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Voltage‐sensitive elevation of cytosolic [Ca2+] in guinea‐pig cardiac myocytes elicited by calcitonin gene‐related peptide

Author(s) -

Gill JS,

Moonga BS,

Huang CL,

Lu F,

Zaidi M,

Camm AJ

Publication year - 1992

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/expphysiol.1992.sp003661

Subject(s) - depolarization , calcitonin gene related peptide , cytosol , calcitonin , guinea pig , myocyte , medicine , endocrinology , peptide , chemistry , calcium , biophysics , biology , neuropeptide , biochemistry , receptor , enzyme

We have studied the effect of the 37‐amino acid cardioactive peptide, calcitonin gene‐related peptide (CGRP) on cytosolic [Ca2+] in guinea‐pig ventricular myocytes following depolarization. Cytosolic [Ca2+] was measured in single myocytes using fura‐2. The application of 20 mM K+ led to a transient rise of cytosolic [Ca2+] followed by an exponential decline. The subsequent application of 2 nM CGRP resulted in a marked increase in cytosolic [Ca2+]. In contrast, no such response was obtained without prior depolarization. The results suggest a basis for the cardiotropic effects of CGRP through an influence on cytosolic [Ca2+].

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