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An analysis of the action of an analogue of almitrine bismesylate in the rat model of hypoxic lung disease
Author(s) -
Bee D,
Emery CJ,
Howard P
Publication year - 1992
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1992.sp003648
Subject(s) - hypoxic pulmonary vasoconstriction , hypoxia (environmental) , medicine , lung , anesthesia , ventilation (architecture) , peripheral chemoreceptors , peripheral , chemoreceptor , chemistry , oxygen , receptor , mechanical engineering , organic chemistry , engineering
Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water‐soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses of S9581 and almitrine enhanced the hypoxic ventilatory response in CH rats while high doses depressed it in both groups. Effects of S9581 on the pulmonary circulation were assessed in the isolated perfused lung of rats. As with almitrine a complex relationship of dose‐dependent vasoconstriction and dilatation was revealed. In low doses, S9581 enhanced the hypoxic pulmonary vasoconstrictor response to 2% O2 whilst this was attenuated by high doses in both control and CH rats. S9581 seemed to act like almitrine bismesylate on both the ventilation (peripheral chemoreceptor) and the pulmonary circulation. For studying almitrine‐like activity the water solubility of S9581 provides considerable advantages for the researcher.