Enhanced electrogenic secretion in vitro by small intestine from glucagon‐treated rats: implications for the diarrhoea of starvation | Zendy

Lane A | Zendy; Levin RJ | Zendy

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Enhanced electrogenic secretion in vitro by small intestine from glucagon‐treated rats: implications for the diarrhoea of starvation

Author(s) -

Lane A,

Levin RJ

Publication year - 1992

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/expphysiol.1992.sp003628

Subject(s) - bethanechol , medicine , endocrinology , glucagon , starvation , ileum , jejunum , basal (medicine) , stimulation , in vitro , muscarinic acetylcholine receptor , secretion , pilocarpine , chemistry , biology , biochemistry , receptor , hormone , insulin , neuroscience , epilepsy

Glucagon treatment of fed rats (50 micrograms I.P. every 6 h for 3 days) induces significant increases in vitro of the basal short‐circuit currents of the jejunum (52%) and proximal ileum (81%) and in their electrogenic secretory responses to stimulation by bethanechol, a muscarinic agonist. The results support a role for glucagon in the intestinal hypersecretion observed in starvation and nutrient deprivation.

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