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Enhanced electrogenic secretion in vitro by small intestine from glucagon‐treated rats: implications for the diarrhoea of starvation
Author(s) -
Lane A,
Levin RJ
Publication year - 1992
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1992.sp003628
Subject(s) - bethanechol , medicine , endocrinology , glucagon , starvation , ileum , jejunum , basal (medicine) , stimulation , in vitro , muscarinic acetylcholine receptor , secretion , pilocarpine , chemistry , biology , biochemistry , receptor , hormone , insulin , neuroscience , epilepsy
Glucagon treatment of fed rats (50 micrograms I.P. every 6 h for 3 days) induces significant increases in vitro of the basal short‐circuit currents of the jejunum (52%) and proximal ileum (81%) and in their electrogenic secretory responses to stimulation by bethanechol, a muscarinic agonist. The results support a role for glucagon in the intestinal hypersecretion observed in starvation and nutrient deprivation.