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Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)‐ and (1S,3R)‐ACPD
Author(s) -
Pook PC,
Sunter DC,
Udvarhelyi PM,
Watkins JC
Publication year - 1992
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1992.sp003617
Subject(s) - excitatory postsynaptic potential , acpd , neuroscience , spinal cord , receptor , biology , glutamate receptor , chemistry , biophysics , biochemistry , metabotropic glutamate receptor , inhibitory postsynaptic potential
Both the (1S,3S) and (1S,3R) stereoisomers of 1‐aminocyclopentane‐1,3‐dicarboxylate (ACPD), but not the (1R,3R) or (1R,3S) isomers, potently depress the fastest (presumed monosynaptic) component of dorsal root‐evoked ventral root potentials in hemisected isolated spinal cord of the newborn rat. This effect is not due to antagonism of known excitatory amino acid (EAA) receptors on motoneurones and may reflect an action of the two ACPD isomers at presynaptic EAA receptors of the L‐2‐amino‐4‐phosphonobutyrate (L‐AP4) type.