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Appearance of phloridzin‐sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes
Author(s) -
Smith MW,
Turvey A,
Freeman TC
Publication year - 1992
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1992.sp003616
Subject(s) - glucose transporter , messenger rna , enterocyte , crypt , small intestine , jejunum , transporter , medicine , endocrinology , rabbit (cipher) , biology , chemistry , microbiology and biotechnology , biochemistry , gene , insulin , statistics , mathematics
Glucose uptake by rabbit intestine has been shown to be confined to the upper two‐thirds of jejunal villi. Inhibition by phloridzin shows most of this transport to take place through the Na(+)‐glucose linked transporter (SGLT1). Parallel measurements on the other hand show SGLT1 mRNA expression to increase rapidly as enterocytes reach the crypt‐villus junction. Levels of SGLT1 mRNA then remain elevated in all villus enterocytes. These results provide direct evidence that SGLT1‐mediated glucose transport is subject to post‐transcriptional control.