Premium
Parathyroid hormone‐related peptide increases urinary phosphate excretion in fetal lambs
Author(s) -
Davicco MJ,
Coxam V,
Lefaivre J,
Barlet JP
Publication year - 1992
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1992.sp003598
Subject(s) - endocrinology , medicine , fetus , chemistry , parathyroid hormone , hypercalcaemia , in utero , excretion , diuresis , urinary system , biology , calcium , kidney , pregnancy , genetics
The effect of synthetic human parathyroid hormone‐related peptide fragment 1–34 (hPTHrP) on plasma concentration and urinary excretion of inorganic phosphorus (P) was compared to that of synthetic bovine PTH fragment 1‐34 (bPTH) in four 120‐ to 130‐day‐old fetal lambs chronically catheterized in utero. They received by I.V. infusion according to a Latin square design either bPTH (6 nmol per fetus) or hPTHrp (6 nmol per fetus) alone, or after the synthetic analogue [Tyr34]bPTH(7–34)NH2 (12 nmol per fetus). Control fetuses received the same volume of solvent alone. Both bPTH and hPTHrP stimulated diuresis. They induced hypercalcaemia, hyperphosphaturia and hypophosphataemia. The effects of hPTHrP were inhibited by [Tyr34]bPTH(7–34)NH2, indicating that PTHrP might work through the PTH receptor.