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Stretch‐induced increase of resting intracellular calcium concentration in single guinea‐pig ventricular myocytes
Author(s) -
Le Guennec JY,
White E,
Gannier F,
Argibay JA,
Garnier D
Publication year - 1991
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1991.sp003560
Subject(s) - guinea pig , calcium , medicine , myocyte , intracellular , calcium in biology , endocrinology , chemistry , resting potential , cardiology , biology , electrophysiology , biochemistry
Single guinea‐pig ventricular myocytes were loaded with the fluorescent Ca2+ indicator Indo‐1 AM and stretched by carbon fibres. Stretching increased resting tension. Sarcomere lengths were increased by 2‐18%. It was observed that a stretch increased resting [Ca2+]i in seven out of eight cells. The change in [Ca2+]i increased with the size of the stretch and returned to pre‐stretch levels on return to resting cell length. These observations suggest a means by which changes in resting muscle length can modify the contractile state of cardiac muscle.