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Evidence for volume regulatory increase by Na‐K‐Cl co‐transport in rat arterial smooth muscle
Author(s) -
Chipperfield AR,
Davis JP,
Harper AA
Publication year - 1991
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1991.sp003559
Subject(s) - efflux , tonicity , medicine , chemistry , potassium , endocrinology , ion transporter , sucrose , biophysics , biology , biochemistry , membrane , organic chemistry
A component of K efflux (86Rb as tracer) from rat femoral arterial smooth muscle was blocked by loop diuretics. Following hypertonic challenge with 100 mM‐sucrose, K efflux increased but not in the presence of loop diuretics. This is taken as evidence for a volume regulatory increase mediated by Na‐K‐Cl co‐transport.