Inhibition of Ca2+ mobilization by caffeine in a cultured vascular smooth muscle cell line (A7r5) | Zendy

Otun H | Zendy; Gillespie JI | Zendy; Dunlop W | Zendy

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Inhibition of Ca2+ mobilization by caffeine in a cultured vascular smooth muscle cell line (A7r5)

Author(s) -

Otun H,

Gillespie JI,

Dunlop W

Publication year - 1991

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/expphysiol.1991.sp003547

Subject(s) - caffeine , forskolin , vascular smooth muscle , vasopressin , endocrinology , medicine , intracellular , calcium , agonist , calcium in biology , chemistry , stimulation , arginine , biology , microbiology and biotechnology , receptor , smooth muscle , biochemistry , amino acid

The effects of caffeine on the resting level and agonist‐induced changes in intracellular calcium ([Ca2+]i) have been studied in the vascular smooth muscle cell line A7r5. Caffeine (1‐30 mM) lowers the resting [Ca2+]i by reducing the entry of Ca2+ and inhibits completely the mobilization of Ca2+ by arginine vasopressin. Application of forskolin, to elevate cAMP, does not affect the resting level of Ca2+i but does abolish the agonist‐induced rise. These data add to the complexity of caffeine‐induced changes in [Ca2+]i and point to a possible interaction between cAMP and other second messenger systems mobilizing Ca2+i in this cell type.

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