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The role of calcitonin gene‐related peptide in gastric mucosal protection in the rat
Author(s) -
Forster ER,
Dockray GJ
Publication year - 1991
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1991.sp003532
Subject(s) - calcitonin gene related peptide , calcitonin , gastric mucosa , endocrinology , medicine , peptide , afferent , antibody , gene , neuropeptide , biology , chemistry , stomach , receptor , immunology , biochemistry
The presence of circulating antibodies to calcitonin gene‐related peptide (CGRP) enhanced the damaging effect of ethanol on the rat gastric mucosa. Taken together with previous experimental and morphological data the results suggest that CGRP released from the peripheral terminals of visceral afferent fibres plays a role in mediating gastric mucosal defence mechanisms.