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Influence of ileal resection, type of diet and ursodeoxycholic acid on biliary secretion in rats
Author(s) -
Lisbona F,
Campos MS,
Coves F,
Garcia JA,
Barrionuevo M,
Lopez-Aliaga I
Publication year - 1991
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1991.sp003523
Subject(s) - ursodeoxycholic acid , bile acid , medicine , sunflower oil , endocrinology , small intestine , secretion , biology , chemistry , gastroenterology , biochemistry
We studied the effects of the type of dietary fat and of ursodeoxycholic acid, an exogenous bile acid added to the diet, on bile physiology in rats with 50% resection of the distal small intestine. The amount of fat was the same (4%) in all diets assayed, which differed only in the type of fat, (olive oil in diet A, and 1/3 medium‐chain triglycerides, 1/3 sunflower oil and 1/3 olive oil in diet B). The removal of 50% of the distal small intestine raised the de novo hepatic synthesis of bile acids with respect to controls, regardless of whether diet A or diet B was given. The addition to diet B of ursodeoxycholic acid decreased bile flow and osmotic activity of bile acid in resected rats and raised bile acid‐independent bile flow in comparison to resected rats given diet B without ursodeoxycholic acid.