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Comparison of a single‐injection technique and inulin clearance for determining glomerular filtration rate in the sheep
Author(s) -
Wholohan T,
Yesberg NE,
Cross RB
Publication year - 1991
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1991.sp003497
Subject(s) - inulin , renal function , chemistry , clearance , filtration (mathematics) , clearance rate , medicine , chromatography , urology , endocrinology , biochemistry , mathematics , statistics
Glomerular filtration rate (GFR) was assessed over a 2 h period by the clearance of inulin (Cin) and in the subsequent 2 h period by a single‐injection technique using radiolabelled sodium iothalamate (Ciot) or chromium‐EDTA (CEDTA). Regression analysis yielded a significant correlation (P less than 0.05) between the standard clearance technique and the single‐injection method, with the relationship Ciot = ‐10.67 + 1.25Cin with a significant correlation coefficient of r = 0.71 (P less than 0.02). There was better agreement between clearance values of inulin measured on successive days than between values determined by the single‐injection technique on successive days. Cin remains the method of choice in sheep.