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MDL 72222 (a selective 5‐HT3 receptor antagonist) prevents stimulation of intrapulmonary C fibres by pulmonary embolization in anaesthetized rabbits
Author(s) -
Kay IS,
Armstrong DJ
Publication year - 1991
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1991.sp003487
Subject(s) - stimulation , receptor antagonist , receptor , antagonist , pulmonary embolism , ketanserin , lung , 5 ht receptor , pharmacology , medicine , anesthesia , chemistry , biology , serotonin
We have investigated the effects of the intravenous administration of 5‐hydroxytryptamine upon the discharge frequency of pulmonary stretch receptors, irritant receptors and C fibres. Only C fibres were stimulated by this autacoid. MDL 72222 a selective 5‐HT3 receptor antagonist blocks the C fibre stimulation by 5‐hydroxytryptamine. It also blocks the C fibre response to miliary pulmonary embolism. These data confirm the hypothesis that 5‐hydroxytryptamine is the humoral link between pulmonary embolism and tachypnoea.