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Intracellular sodium activity in papillary muscle from diabetic rat hearts
Author(s) -
Lagadic-Gossmann D,
Feuvray D
Publication year - 1991
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1991.sp003478
Subject(s) - intracellular , papillary muscle , sodium , medicine , chemistry , endocrinology , cardiology , biochemistry , organic chemistry
In quiescent papillary muscles isolated from hearts of rats with streptozotocin‐induced diabetes resting intracellular sodium activity (aiNa) was about 56% greater than in muscles from controls. An intracellular acid load induced by the NH4+ method caused a rise in aiNa whose maximum amplitude was similar in both groups of muscles. However, the half‐time to maximum amplitude was increased by about 56% in diabetic muscles. These results are consistent with a diabetes‐induced decrease in the activity of the sarcolemmal Na(+)‐H+ exchange.
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