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Calcitonin gene‐related peptide promotes transient radiocalcium uptake into chick bone in vivo
Author(s) -
Ancill AK,
Bascal ZA,
Whitaker G,
Dacke CG
Publication year - 1991
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1991.sp003477
Subject(s) - in vivo , calcitonin , calcitonin gene related peptide , endocrinology , medicine , peptide , chemistry , microbiology and biotechnology , biology , biochemistry , neuropeptide , genetics , receptor
We have examined the in vivo effects in chicks of intravenously injected chicken (c‐) and rat (r‐) calcitonin gene‐related peptides (CGRP) on uptake into bone of a simultaneously administered 45Ca label. Both peptides caused transient (10 min) increases in 45Ca uptake into a variety of bone types. In dose‐response experiments at 10 min, CGRP doses of 0.26‐1.04 nmol/100 g body wt were found to give maximal responses. These were well developed in chicks fasted for 22 h but absent in those which were continuously fed. This contrasts with the hypercalcaemic effect of CGRP which is apparent in fed rather than fasted chicks.