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Dissociation between plasma concentrations of thyroxine and insulin‐like growth factor‐I
Author(s) -
Dauncey MJ,
Morovat A,
Rudd BT,
Shakespear RA
Publication year - 1990
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1990.sp003454
Subject(s) - medicine , endocrinology , euthyroid , insulin like growth factor , insulin , food intake , chemistry , plasma concentration , plasma levels , growth factor , thyroid , receptor
The relation between plasma concentrations of thyroxine (T4) and insulin‐like growth factor‐I (IGF‐I) has been examined in young, growing pigs under controlled conditions of energy intake. Compared with euthyroid controls, plasma levels of IGF‐I were significantly elevated (P less than 0.005) both in hypothyroid animals on the same food intake and in hyperthyroid animals on double the food intake. There was however no increase in IGF‐I in a hyperthyroid group on the control level of intake. Contrary to previous reports in which energy intake was not controlled, it is concluded that there is no simple correlation between plasma concentrations of T4 and IGF‐I.