Premium
Coronary myogenic responses to abrupt changes in aortic blood pressure in anaesthetized dogs
Author(s) -
Dambrosio M,
Gattullo D,
Linden RJ,
Losano G,
Pagliaro P,
Vono P
Publication year - 1990
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1990.sp003453
Subject(s) - cardiology , hyperaemia , aortic pressure , medicine , blood pressure , coronary occlusion , blood flow , occlusion , aorta , vascular resistance , coronary circulation , anesthesia
A transient increase in coronary transmural pressure was produced in anaesthetized dogs by occlusion of the descending thoracic aorta. Aortic blood pressure (ABP), left ventricular pressure and coronary flow were measured; coronary vascular resistance (CVR) was calculated. Results were similar in innervated and denervated hearts. Occlusion for 10 and 20 s resulted in no change in CVR for 15 s, followed by a metabolic dilatation attributable to enhanced oxygen demand; after release the fall in ABP resulted in an immediate increase in CVR, caused by vascular elastic recoil, followed by hyperaemia.