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Behavioural thermoregulation in mice: effects of low doses of general anaesthetics of different potency
Author(s) -
Pertwee RG,
Marshall NR,
Macdonald AG
Publication year - 1990
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1990.sp003441
Subject(s) - potency , hypothermia , thermoregulation , rectal temperature , nitrous oxide , chemistry , anesthesia , pharmacology , zoology , medicine , endocrinology , biology , biochemistry , in vitro
Chloroform, monochlorodifluoromethane and nitrous oxide produced dose‐related decreases in the rectal temperatures of mice allowed to choose between a warm and a cool environment. The doses used were subanaesthetic, respectively 0.0013‐0.004, 0.028‐0.085 and 0.25‐0.5 atm. The hypothermia (up to 3.6 degrees C) was usually associated with significant reductions in time spent in the warm. The log dose‐hypothermic response plots were approximately parallel and there was a marked correlation between anaesthetic potency, as measured by the abolition of the righting response, and hypothermic potency.