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Stimulation of ovine placental transport of calcium and magnesium by mid‐molecule fragments of human parathyroid hormone‐related protein
Author(s) -
Care AD,
Abbas SK,
Pickard DW,
Barri M,
Drinkhill M,
Findlay JB,
White IR,
Caple IW
Publication year - 1990
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1990.sp003437
Subject(s) - placenta , endocrinology , medicine , stimulation , calcium , fetus , chemistry , parathyroid hormone , perfusion , biology , pregnancy , genetics
Perfusion in situ of the placenta of intact or previously parathyroidectomized fetal lambs has been used to assess the ability of three mid‐molecule fragments of the human parathyroid hormone‐related protein (PTHrP) molecule to stimulate the placental transport of calcium and magnesium. PTHrP(67‐86 amide) was most effective but some activity was also shown by PTHrP(75‐86 amide) and by PTHrP (75‐84) in decreasing order. This placental action of PTHrP(67‐86 amide) was rapid and could be observed using the placenta from an intact fetus, whereas it was necessary to use the placenta from a previously parathyroidectomized fetus to demonstrate stimulation of placental calcium transport by PTHrP(1‐84). PTHrP(67‐86 amide) may resemble the molecule that activates the placental calcium pump.