Vasoactive intestinal peptide stimulation of adenylate cyclase activity in isolated rabbit renal arterial microvessels | Zendy

Griffiths NM | Zendy; Simmons NL | Zendy

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Vasoactive intestinal peptide stimulation of adenylate cyclase activity in isolated rabbit renal arterial microvessels

Author(s) -

Griffiths NM,

Simmons NL

Publication year - 1990

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/expphysiol.1990.sp003436

Subject(s) - vasoactive intestinal peptide , endocrinology , medicine , stimulation , adenylate kinase , cyclase , receptor , chemistry , antagonist , vasoactive , basal (medicine) , neuropeptide , biology , insulin

Vasoactive intestinal peptide (VIP) at a concentration of 1 microM stimulates adenylate cyclase (AC) in isolated rabbit renal preglomerular arterial vessels by 3.9 +/‐ 1.3 fold (n = 6) over basal values. A comparable stimulation of AC was observed with prostaglandin E1. Half‐maximal VIP‐stimulated activity was observed at 7.2 +/‐ 3.5 nM (n = 6), which was increased to 17.4 +/‐ 4.4 nM by 10 microM‐(4Cl‐D‐Phe6,Leu17)VIP, a VIP‐receptor antagonist.

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