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Vasoactive intestinal peptide stimulation of adenylate cyclase activity in isolated rabbit renal arterial microvessels
Author(s) -
Griffiths NM,
Simmons NL
Publication year - 1990
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1990.sp003436
Subject(s) - vasoactive intestinal peptide , endocrinology , medicine , stimulation , adenylate kinase , cyclase , receptor , chemistry , antagonist , vasoactive , basal (medicine) , neuropeptide , biology , insulin
Vasoactive intestinal peptide (VIP) at a concentration of 1 microM stimulates adenylate cyclase (AC) in isolated rabbit renal preglomerular arterial vessels by 3.9 +/‐ 1.3 fold (n = 6) over basal values. A comparable stimulation of AC was observed with prostaglandin E1. Half‐maximal VIP‐stimulated activity was observed at 7.2 +/‐ 3.5 nM (n = 6), which was increased to 17.4 +/‐ 4.4 nM by 10 microM‐(4Cl‐D‐Phe6,Leu17)VIP, a VIP‐receptor antagonist.