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Unreliability of lithium clearance as a marker of proximal tubular function during haemorrhagic hypotension in the rat
Author(s) -
Walter SJ,
Shirley DG
Publication year - 1990
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1990.sp003404
Subject(s) - reabsorption , lithium (medication) , medicine , endocrinology , excretion , chemistry , renal physiology , renal function , kidney
Fractional lithium excretion (FELi) was measured before and after hypotensive haemorrhage (15 ml (kg body wt)‐1) in anaesthetized Brattleboro rats; simultaneously, micropuncture collections were made from late proximal convoluted tubules. Micropuncture data indicated that fractional reabsorption in the proximal convoluted tubules was not affected significantly by haemorrhage, whereas FELi fell from 0.25 +/‐ 0.02 (mean +/‐ S.E.M.; control period) to 0.03 +/‐ 0.01. In time‐control animals, no significant change in either variable was observed. These results suggest that lithium clearance is an unreliable marker of proximal tubular function during haemorrhagic hypotension.