Premium
Histamine‐evoked amylase secretion is associated with small changes in calcium mobilization in isolated guinea‐pig pancreas
Author(s) -
Salido G,
Lennard R,
Singh J,
Pariente JA
Publication year - 1990
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1990.sp003401
Subject(s) - histamine , guinea pig , acetylcholine , endocrinology , medicine , amylase , calcium , pancreas , secretion , chemistry , mobilization , cytosol , biology , biochemistry , enzyme , history , archaeology
An investigation was made of the effect of histamine on amylase secretion and calcium mobilization in isolated guinea‐pig pancreatic segments. The effect of acetylcholine (ACh) was also examined for comparison. Histamine evoked a dose‐dependent increase in amylase output from superfused segments. It had small transient effects on both 45Ca influx and efflux, and elevated cytosolic free Ca2+ concentration in acini. The equivalent dose of ACh evoked a greater amylase output and greater changes in Ca2+ mobilization. The results suggest that histamine may have a physiological role in exocrine secretion of the guinea‐pig pancreas but is less potent than ACh.