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Possible lymphocyte effects on lactase expression by mouse jejunal enterocytes
Author(s) -
Savidge TC,
Smith MW,
Kilshaw PJ
Publication year - 1990
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1990.sp003377
Subject(s) - lactase , intraepithelial lymphocyte , biology , parasite hosting , lymphocyte , immune system , immunology , biochemistry , enzyme , world wide web , computer science
Jejunal intraepithelial lymphocyte numbers fall and lactase activity increases during early infection with the intestinal parasite Nematospiroides dubius. Both these variables later return to values found in control mice. These results support the view that local immune reactions, suppressed by the presence of N. dubius, normally inhibit lactase expression by mouse enterocytes.
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