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SOMATOSTATIN AND ITS ANALOGUE (D‐Trp 8 ,D‐Cys 14 ‐SOMATOSTATIN DO NOT MODIFY INTESTINAL ABSORPTION IN VIVO OF CARBOHYDRATES IN HAMSTER INTESTINE, BUT THEY DO MODIFY SOME DISACCHARIDASES
Author(s) -
MartíNez-Sapiña J.,
Vieytes M. R.,
Taboada M. C.
Publication year - 1989
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1989.sp003355
Subject(s) - somatostatin , maltase , medicine , endocrinology , disaccharidase , in vivo , sucrase , brush border , hormone , chemistry , ileum , small intestine , biology , biochemistry , vesicle , enzyme , membrane , microbiology and biotechnology
Somatostatin is a widely distributed hormone localized in the central nervous system, pancreas and gastrointestinal tract. We have investigated the possible influence of somatostatin and a synthetic analogue, (D‐Trp 8 ,D‐Cys 14 )‐somatostatin, on the intestinal absorption ‘in vivo’ of D(+)‐glucose and D(+)‐galactose and also the effect on disaccharidase intestinal activities in hamster. Somatostatin, or its analogue, (12 µg/100 g body wt) was administered intraperitoneally 4 or 14 h prior to experiments. The results are compared to control animals. Animals treated with somatostatin and the synthetic analogue showed that there were no significant difference from control animals with respect to intestinal absorption of carbohydrates. Somatostatin produced inhibition of brush‐border lactase activity in females only, whereas brush‐border sucrase was increased 14 h after treatment in males and females, and brush‐border maltase was inhibited in females only 4 h after hormone administration.