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ROLE OF CHLORIDE IN HYPERTONICITY‐INDUCED CONTRACTURES OF RAT SOLEUS MUSCLE
Author(s) -
Bruton J. D.
Publication year - 1989
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1989.sp003307
Subject(s) - muscle contracture , tonicity , mannitol , chemistry , sucrose , soleus muscle , urea , chloride , biochemistry , medicine , endocrinology , anatomy , skeletal muscle , organic chemistry
The role of chloride in contractures induced in rat soleus muscle by mannitol‐, sucrose‐ or urea‐containing hypertonic solutions was investigated. Replacement of chloride with nitrate, sulphate or perchlorate reduced the amplitude of mannitol‐ and sucrose‐induced contractures, and the first phase of contractures induced by urea. Addition of 9‐anthracene carboxylic acid had similar effects. The presence of diazepam increased the amplitude of ‘hypertonic’ contractures. The results show that chloride is important in the development of hypertonic contractures.