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AMILORIDE REDUCES MATERNOFETAL CLEARANCE OF SODIUM ACROSS THE NEAR‐TERM RAT PLACENTA
Author(s) -
Atkinson D. E.,
Sibley C. P.,
Robinson N. R.
Publication year - 1989
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1989.sp003305
Subject(s) - amiloride , saline , placenta , bolus (digestion) , chemistry , endocrinology , medicine , sodium , gestation , intravenous bolus , fetus , pregnancy , biology , organic chemistry , genetics
The effect of amiloride on unidirectional maternofetal clearance across the perfused placenta has been studied in rats at 21 days gestation. A bolus dose of 1 mg kg −1 followed by an infusion of 0·6 mg h −1 into the maternal circulation caused a significant ( P 〈 0·02) decrease in 22 Na clearance by 8%, whilst having no effect on the clearance of 51 Cr‐EDTA; a ten times higher dose of amiloride (10 mg kg ∓1 , 6 mg h −1 ) did not reduce 22 Na clearance further. Similar administration of an equivalent volume of saline to control animals showed no effect on either Na + or Cr‐EDTA clearances.