AMILORIDE REDUCES MATERNOFETAL CLEARANCE OF SODIUM ACROSS THE NEAR‐TERM RAT PLACENTA | Zendy

Atkinson D. E. | Zendy; Sibley C. P. | Zendy; Robinson N. R. | Zendy

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AMILORIDE REDUCES MATERNOFETAL CLEARANCE OF SODIUM ACROSS THE NEAR‐TERM RAT PLACENTA

Author(s) -

Atkinson D. E.,

Sibley C. P.,

Robinson N. R.

Publication year - 1989

Publication title -

quarterly journal of experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0144-8757

DOI - 10.1113/expphysiol.1989.sp003305

Subject(s) - amiloride , saline , placenta , bolus (digestion) , chemistry , endocrinology , medicine , sodium , gestation , intravenous bolus , fetus , pregnancy , biology , organic chemistry , genetics

The effect of amiloride on unidirectional maternofetal clearance across the perfused placenta has been studied in rats at 21 days gestation. A bolus dose of 1 mg kg −1 followed by an infusion of 0·6 mg h −1 into the maternal circulation caused a significant ( P 〈 0·02) decrease in 22 Na clearance by 8%, whilst having no effect on the clearance of 51 Cr‐EDTA; a ten times higher dose of amiloride (10 mg kg ∓1 , 6 mg h −1 ) did not reduce 22 Na clearance further. Similar administration of an equivalent volume of saline to control animals showed no effect on either Na + or Cr‐EDTA clearances.

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