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THE CONTROL OF POTASSIUM (86Rb+) EFFLUX IN THE ISOLATED HUMAN SWEAT GLAND
Author(s) -
Bovell Douglas L.,
Elder Hugh Y.,
Jenkinson David McEwan,
Wilson Stuart M.
Publication year - 1989
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1989.sp003270
Subject(s) - efflux , potassium , chemistry , saline , endocrinology , calcium , medicine , sodium , sweat , permeability (electromagnetism) , acetylcholine , ion transporter , biophysics , biology , biochemistry , membrane , organic chemistry
Sweat glands, isolated from strips of human skin and pre‐loaded with 86 Rb + , a marker of potassium transport, were superfused with physiological saline and rate constants for 86 Rb + efflux calculated. The rate of efflux during superfusion with Ca 2+ −free saline was lower than that measured in the presence of calcium (2·56 mM). Acetylcholine increased the rate of 86 Rb + efflux and this response could be resolved into two components: an initial transient phase which was Ca 2+ −independent and a slowly declining Ca 2+ −dependent phase. Adrenaline only caused a Ca 2+ −dependent increase in efflux. It is suggested that the potassium permeability of the secretory cells increases during activity.