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ADAPTATION AND BURSTING IN NEOCORTICAL NEURONES MAY BE CONTROLLED BY A SINGLE FAST POTASSIUM CONDUCTANCE
Author(s) -
Berman N. J.,
Bush P. C.,
Douglas R. J.
Publication year - 1989
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1989.sp003260
Subject(s) - bursting , neuroscience , conductance , intracellular , potassium , adaptation (eye) , biophysics , calcium , neocortex , chemistry , biology , physics , microbiology and biotechnology , organic chemistry , condensed matter physics
We have used computer simulation of a model neurone and in vitro intracellular recording to demonstrate that the adaptation of repetitive discharge in neocortical neurones can be explained by a fast potassium current whose inactivation is retarded by intracellular calcium. The maximum amplitude of this current determines whether the neurone will discharge in regular or burst mode.