Premium
EFFECT OF MAGNESIUM INFUSION ON CALCIUM HANDLING IN THE RAT KIDNEY
Author(s) -
Shafik I.,
Green R.
Publication year - 1989
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1989.sp003235
Subject(s) - magnesium , calcium , chemistry , renal function , potassium , excretion , urine , endocrinology , urine flow rate , medicine , reabsorption , sodium , saline , kidney , renal physiology , biochemistry , organic chemistry
Anaesthesized rats were infused with 100 µl min -1 of 0·9% saline or saline containing 2 or 4 mmol l −1 of magnesium chloride and renal function was studied. Magnesium had no effect on urine flow rate, excretion of sodium or potassium, or glomerular filtration rate (GFR). Infusion of either dose of magnesium increased calcium excretion and calcium concentration in the urine. The increased urinary calcium excretion is due to a decrease in tubular reabsorption of calcium.