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A STUDY OF THE RENAL RESPONSES IN THE RAT TO ELECTRICAL STIMULATION OF THE AFFERENT NERVES OF THE BRACHIAL PLEXUS
Author(s) -
Handa Rajash K.,
Johns Edward J.
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003226
Subject(s) - stimulation , denervation , renal sodium reabsorption , blood pressure , renal blood flow , medicine , endocrinology , renal physiology , kidney , reabsorption , blood flow , renal function , sodium , hemodynamics , brachial plexus , chemistry , anesthesia , organic chemistry
Brachial nerve stimulation at 3 Hz in sodium pentobarbitone‐anaesthetized rats, with constant renal arterial pressure, increased systemic blood pressure, did not alter glomerular filtration rate but reduced renal blood flow, absolute and fractional sodium excretions and urine flow. In renally denervated animals, stimulation caused similar changes in blood pressure and renal haemodynamics but significantly smaller reductions in sodium and water excretions. Brachial nerve stimulation at 30 Hz caused changes in blood pressure and renal function identical to those obtained with low‐frequency stimulation but these responses were not modified by renal denervation. The results show that renal nerves are necessary to promote sodium and water reabsorption in response to low‐but not high‐frequency stimulation of the brachial nerves in the rat.