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A NEW FORM OF ASYMMETRY IN EPITHELIA: KINETICS OF APICAL AND BASAL SULPHATE TRANSPORT IN HUMAN PLACENTA
Author(s) -
Bustamante J. C.,
Yudilevich D. L.,
Boyd C. A. R.
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003212
Subject(s) - basal (medicine) , kinetics , human placenta , microbiology and biotechnology , placenta , chemistry , basal plate (neural tube) , biophysics , biology , fetus , endocrinology , physics , pregnancy , genetics , quantum mechanics , insulin
Sulphate transport into and out of membrane vesicles prepared from both the brush‐border and basal surfaces of the human placental trophoblast has been studied. For both surfaces of this epithelium clear evidence of trans ‐stimulation of influx is seen but for efflux, acceleration of labelled sulphate movement by addition of external sulphate is seen only in basal and not in brush‐border membrane vesicles. This kinetic asymmetry may underlie the previously observed, but unexplained, finding that the concentration of sulphate is greater in the fetal than in the maternal circulation.