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RECOVERY FROM IMMOBILIZATION‐INDUCED ATROPHY OF RABBIT SOLEUS MUSCLES CAN BE ACCELERATED BY CHRONIC LOW‐FREQUENCY STIMULATION
Author(s) -
Cotter Mary,
Barry Jacqueline,
Cameron Norman
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003202
Subject(s) - soleus muscle , stimulation , ankle , atrophy , regeneration (biology) , degeneration (medical) , hindlimb , medicine , anatomy , endocrinology , chemistry , biology , skeletal muscle , pathology , microbiology and biotechnology
Immobilization of rabbit soleus muscles with an ankle joint angle of 90° led to gross degeneration after 2 weeks. Natural recovery in the subsequent 2 weeks had little effect on the mean area of soleus fibres, although there were signs of regeneration. However chronic low‐frequency activation of soleus muscles by nerve stimulation greatly accelerated recovery, producing muscle fibres of normal areas and with characteristics of maturity.