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THE EFFECT OF HYPOXIA ON PLASMA POTASSIUM CONCENTRATION AND THE EXCITATION OF ARTERIAL CHEMORECEPTORS IN THE CAT
Author(s) -
Paterson David J.,
Nye Piers C. G.,
Estavillo Jaime A.
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003182
Subject(s) - hypoxia (environmental) , chemoreceptor , potassium , medicine , chemistry , oxygen , receptor , organic chemistry
Intra‐arterial recordings of potassium concentration ([K + ] a ) and arterial chemoreceptor discharge were made in six anaesthetized cats while tracheal P O2 was stepped every 2 min (end‐tidal P O2 ca . 140, 60, 40 and 95 Torr) at constant PCO2 (33 Torr). [K+]a increased hyperbolically from 3·0 mM to 4·5 mM as arterial P O2 was lowered from 95 to 40 Torr. Because the discharge of arterial chemoreceptors is excited by hyperkalaemia as well as hypoxia, the hypoxic discharge of arterial chemoreceptors may have a component mediated by [K + ] a . The mechanisms underlying the arterial K + increase in hypoxia remain unknown.