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TIME COURSE OF THE CHANGE IN NUCLEAR 3,5,3'‐TRIIODOTHYRONINE RECEPTORS OF SKELETAL MUSCLE IN RELATION TO ENERGY INTAKE
Author(s) -
Geers R.,
Ingram D. L.,
Dauncey M. J.
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003161
Subject(s) - endocrinology , medicine , triiodothyronine , receptor , skeletal muscle , biology , nuclear receptor , chemistry , thyroid , biochemistry , gene , transcription factor
Nuclear triiodothyronine receptors have been investigated in skeletal muscle from young pigs living at thermal neutrality (26°). Animals were fed at a high (H) or low (L) level of energy intake for 3 or 21 days and killed at 6 or 24 h after the last meal. Receptor numbers were significantly greater on the H than the L intake, even after only 3 days of treatment. The difference in receptors between animals on H and L diets was somewhat less at 6 compared with 24 h after feeding. It is postulated that these changes could be mediated through the action of glucagon.