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THE EFFECT OF HIGH‐FREQUENCY VENTILATION ON PATTERN OF BREATHING OF ANAESTHETIZED RABBITS
Author(s) -
Davies A.,
Dutia M. B.,
Price R. F.
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003151
Subject(s) - expiration , pulmonary stretch receptors , ventilation (architecture) , high frequency ventilation , receptor , medicine , breathing , anesthesia , stimulation , respiration , respiratory system , mechanical ventilation , anatomy , mechanical engineering , engineering
The lungs of anaesthetized rabbits were ventilated with a frequency of 30 Hz and a displacement of 5 ml. High‐frequency ventilation (HFV) was superimposed on static inflation or deflation pressures of 2·5 and 5 cmH 2 O and was maintained for 10 s. Changes in pattern of breathing in response to this procedure were recorded before and during block of pulmonary stretch receptors by SO 2 . With lung stretch receptors intact apnoea or extended duration of expiration demonstrated the predominant role of pulmonary stretch receptors in the response to HFV. Block of stretch receptors exposed effects of other pulmonary afferents, presumably rapidly adapting receptors, during HFV, and demonstrated the influence of their sustained stimulation on pattern of breathing as augmented breaths and the reduction of duration of expiration. High‐frequency ventilation may represent a useful experimental method of stimulating rapidly adapting receptors.