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PROLONGED PRESSOR RESPONSES TO INTRAVENOUSLY INJECTED VASOPRESSIN IN ANAESTHETIZED BRATTLEBORO RATS
Author(s) -
Obika L. F. O.,
Laycock J. F.
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003139
Subject(s) - vasopressin , medicine , pressor response , endocrinology , arginine , peripheral , blood pressure , chemistry , heart rate , biochemistry , amino acid
Randomized intravenous injections of arginine vasopressin, 0·02 to 0·62 , µg/kg, administered to anaesthetized Brattleboro rats genetically lacking vasopressin, produced significantly greater, prolonged dose‐dependent pressor responses than those produced in normal animals of the parent Long‐Evans strain. Dose‐related decreases in cardiac output were transient in both groups of animals but were greater in Brattleboro rats. It is concluded that the enhanced pressor effects in these animals were associated with greater and prolonged increases in the total peripheral resistance.